Establishing quantitative parameters for differentiating between healthy and diseased
cartilage tissues by examining collagen fibril degradation patterns facilitates the …

Osteoarthritis (OA) is a chronic joint disorder involving degeneration of articular cartilage
and subchondral bone in joints. We previously established a second harmonic generation …

Purpose: Osteoarthritis (OA) is a multifaceted disease that involves pathological changes of
multiple tissues in the joint. Most studies on cartilage matrix in OA have focused on changes …

Hyaline cartilage is a semitransparent tissue composed of proteoglycan and thicker type II
collagen fibers, while fibro cartilage large bundles of type I collagen besides other territorial …

Osteoarthritis is one of the most prevalent joint diseases in the world. Although the cause of
osteoarthritis is not exactly clear, the disease results in a degradation of the quality of the …

According to previous studies, the nonlinear susceptibility tensor ratio χ33/χ31 obtained from
polarization‐resolved second harmonic generation (P‐SHG) under the assumption of …

Osteoarthritis (OA) restricts the daily activities of patients and significantly decreases their
quality of life. The development of non-invasive quantitative methods for properly diagnosing …

Many arthroscopic tools developed for knee joint assessment are contact-based, which is
challenging for in vivo application in narrow joint spaces. Second harmonic generation …

Second harmonic microscopy (SHM) has emerged as a powerful non-destructive optical
imaging modality that has high potential to perform the advanced structural characterization …

Collagen is the most abundant structural protein found in the human body, and is
responsible for providing structure and function to tissues. Collagen molecules organize …