A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - Science, 2020 - science.org
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding …

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health …

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein
prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike …

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

A Baum, BO Fulton, E Wloga, R Copin, KE Pascal… - Science, 2020 - science.org
Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 …

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

SJ Zost, P Gilchuk, RE Chen, JB Case, JX Reidy… - Nature medicine, 2020 - nature.com
Antibodies are a principal determinant of immunity for most RNA viruses and have promise
to reduce infection or disease during major epidemics. The novel coronavirus SARS-CoV-2 …

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv… - Science, 2020 - science.org
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome–coronavirus 2 (SARS-CoV-2) has now become a pandemic, but there is currently …

Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

D Pinto, YJ Park, M Beltramello, AC Walls, MA Tortorici… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …

A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes

Y Guo, L Huang, G Zhang, Y Yao, H Zhou… - Nature …, 2021 - nature.com
COVID-19 pandemic caused by SARS-CoV-2 constitutes a global public health crisis with
enormous economic consequences. Monoclonal antibodies against SARS-CoV-2 can …

An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer

N Suryadevara, AR Shiakolas… - The Journal of …, 2022 - Am Soc Clin Investig
The protective human antibody response to severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and …

Structural analysis of neutralizing epitopes of the SARS-CoV-2 spike to guide therapy and vaccine design strategies

MT Finkelstein, AG Mermelstein, E Parker Miller… - Viruses, 2021 - mdpi.com
Coronavirus research has gained tremendous attention because of the COVID-19
pandemic, caused by the novel severe acute respiratory syndrome coronavirus (nCoV or …