Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11. 2 locus
Both obesity and being underweight have been associated with increased mortality,.
Underweight, defined as a body mass index (BMI)≤ 18.5 kg per m2 in adults and≤− 2 …
Underweight, defined as a body mass index (BMI)≤ 18.5 kg per m2 in adults and≤− 2 …
A new highly penetrant form of obesity due to deletions on chromosome 16p11. 2
Obesity has become a major worldwide challenge to public health, owing to an interaction
between the Western 'obesogenic'environment and a strong genetic contribution. Recent …
between the Western 'obesogenic'environment and a strong genetic contribution. Recent …
Large, rare chromosomal deletions associated with severe early-onset obesity
EG Bochukova, NI Huang, J Keogh, E Henning… - Nature, 2010 - nature.com
Obesity is a highly heritable and genetically heterogeneous disorder. Here we investigated
the contribution of copy number variation to obesity in 300 Caucasian patients with severe …
the contribution of copy number variation to obesity in 300 Caucasian patients with severe …
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
G Thorleifsson, GB Walters, DF Gudbjartsson… - Nature …, 2009 - nature.com
Obesity results from the interaction of genetic and environmental factors. To search for
sequence variants that affect variation in two common measures of obesity, weight and body …
sequence variants that affect variation in two common measures of obesity, weight and body …
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10
Obesity, a common multifactorial disorder, is a major risk factor for type 2 diabetes,
hypertension and coronary heart disease 1 (CHD). According to the definition of the World …
hypertension and coronary heart disease 1 (CHD). According to the definition of the World …
A supersized list of obesity genes
M Hofker, C Wijmenga - Nature genetics, 2009 - nature.com
A supersized list of obesity genes | Nature Genetics Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …
nature.com. You are using a browser version with limited support for CSS. To obtain the best …
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Genome-wide association studies (GWAS) have identified> 250 loci for body mass index
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
(BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters …
[HTML][HTML] Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
Y Zhao, M Chukanova, KA Kentistou… - Nature Genetics, 2024 - nature.com
Obesity is a major risk factor for many common diseases and has a substantial heritable
component. To identify new genetic determinants, we performed exome-sequence analyses …
component. To identify new genetic determinants, we performed exome-sequence analyses …
Genetic studies of body mass index yield new insights for obesity biology
AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …
obesity better, here we conduct a genome-wide association study and Metabochip meta …
A genome-wide association meta-analysis identifies new childhood obesity loci
Nature genetics, 2012 - nature.com
Multiple genetic variants have been associated with adult obesity and a few with severe
obesity in childhood; however, less progress has been made in establishing genetic …
obesity in childhood; however, less progress has been made in establishing genetic …