Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Highlights•Transcription factors are generally dysregulated in tumors.•Most oncogenic
transcription factors are considered as “undruggable” targets.•Post-translational …

Transcription factors (TFs) act as major oncodrivers in many cancers and are frequently
regarded as high-value therapeutic targets. The functionality of TFs relies on direct protein …

Transcription factors represent the point of convergence of multiple signaling pathways
within eukaryotic cells. Deregulated transcription factors contribute to the pathogenesis of a …

Transcription factors with aberrant activity in disease are promising yet untested targets for
therapeutic development, particularly in oncology. Directly inhibiting or activating the …

Transcription factors comprise just over 7% of the human proteome and serve as
gatekeepers of cellular function, integrating external signal information into gene expression …

Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

Much research on transcription factor biology and their genetic pathways has been
undertaken over the last 30 years, especially in the field of developmental biology and …

Transcription factors (TFs) are families of proteins that bind to specific DNA sequences, or TF
response elements (TFREs), and function as regulators of many cellular processes …