Transcription factors (TFs) regulate gene expression by binding to DNA sequences and
modulating transcriptional activity through their effector domains. Despite the central role of …

Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Transcription factors (TFs) drive various biological processes ranging from embryonic
development to carcinogenesis. Here, we employ a recently developed concatenated …

Following sequencing and assembly of the human genome, the preferred methods for
identification of new drug targets have changed dramatically. Modern tactics such as …

Abstract The TDR Targets Database (http://tdrtargets. org) has been designed and
developed as an online resource to facilitate the rapid identification and prioritization of …

A transcription reaction relies on the specific recognition of cis‐regulatory regions containing
short DNA motifs. Such sequences are bound by transcription factors (TFs) involved in the …

Higher eukaryotic development is a complex and tightly regulated process, whereby
transcription factors (TFs) play a key role in controlling the gene regulatory networks …

Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …

Transcription factors (TFs) represent a major class of therapeutic targets for the treatment of
human diseases including cancer. Although the biological functions and even crystal …

Systematic chromatin immunoprecipitation (chIP-chip) experiments have become a central
technique for mapping transcriptional interactions in model organisms and humans …