The transcriptional effects of SSRIs and other serotonergic drugs remain unclear, in part due
to the heterogeneity of postsynaptic cells, which may respond differently to changes in …

The Serotonin Transporter (SERT) regulates extracellular serotonin levels and is the target
of most current drugs used to treat depression. The mechanisms by which inhibition of SERT …

A better comprehension on how different molecular components of the serotonergic system
contribute to the adequate regulation of behaviors in animals is essential in the …

The serotonin transporter is an important regulator of serotonergic signaling. In order to
analyze where the Drosophila melanogaster ortholog of the mammalian serotonin …

The serotonin transporter knockout (SERT−/−) mouse, generated in 1998, was followed by
the SERT−/− rat, developed in 2006. The availability of SERT−/− rodents creates the unique …

The synaptic machinery for neurotransmitter storage is cell‐type specific. Although most
elements of biosynthesis and transport have been identified, it remains unclear whether …

Selective serotonin reuptake inhibitor (SSRI) antidepressants are commonly prescribed
treatments for depression, but their effects on serotonin reuptake and release are not well …

Rationale A promoter variant of the serotonin transporter (SERT) gene is known to affect
emotional and cognitive regulation. In particular, the “short” allelic variant is implicated in the …

The serotonin system plays a key modulatory role in central nervous system processes that
appear to be dysregulated in psychiatric disorders. Specifically, the serotonin transporter …

Polymorphisms that alter serotonin transporter SERT expression and functionality increase
the risks for autism and psychiatric traits. Here, we investigate how SERT controls serotonin …