We report a new mechanism of androgen receptor (AR) mRNA regulation and cytoprotection
in response to AR pathway inhibition (ARPI) stress in prostate cancer (PCA). AR mRNA …

ABSTRACT The Androgen Receptor (AR), transcriptionally activated by its ligands,
testosterone and dihydrotestosterone (DHT), is widely expressed in cells and tissues …

Stress granules (SGs) are cytoplasmic assemblies of RNA and protein that form when
translation is repressed during the integrated stress response. SGs assemble from the …

During cellular stress, protein synthesis is severely reduced and bulk mRNA is recruited to
stress granules (SGs). Previously, we showed that the SG-recruited IGF2 mRNA-binding …

Abstract Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of
cellular events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) …

Upon stress, cytoplasmic mRNA is sequestered to insoluble ribonucleoprotein (RNP)
granules, such as the stress granule (SG). Partially due to the belief that translationally …

Androgens, via the androgen receptor (AR), modulate the growth and proliferation of
prostate and breast cancer cells. However, the molecular mechanisms underlying the …

The poly (A) tail of mRNAs plays pivotal roles in the posttranscriptional control of gene
expression at both translation and mRNA stability. Recent findings demonstrate that the poly …

Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′
UTR lengths, production of which is influenced by cellular conditions. Here, we show that …

Simple Summary The estrogen and androgen receptors (ER, AR) are key oncogenic drivers
and therapeutic targets in breast and prostate cancer, respectively. These receptors bind to …