Studying lung adenocarcinoma (LUAD) early carcinogenesis is challenging, primarily due to
the lack of LUAD precursors specimens. We amassed multi-omics data from 213 LUAD and …

Background: Lung adenocarcinoma (LUAD) is a leading cause of cancer-related deaths.
Our understanding of LUAD initiation and progression is limited, impeding early diagnosis …

Lung adenocarcinoma (LUAD) is the main non-small-cell lung cancer diagnosed in~ 40–
50% of all lung cancer cases. Despite the improvements in early detection and personalized …

Understanding the earliest changes during lung adenocarcinoma (LUAD) development can
set the stage for discovery of fertile targets for disease interception, thereby mitigating the …

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but …

Background Lung adenocarcinoma (LUAD) is a highly malignant and heterogeneous tumor
that involves various oncogenic genetic alterations. Epigenetic processes play important …

Cancer immunotherapy has demonstrated promising efficacy in the neoadjuvant setting for
treating early-stage non-small cell lung cancer (NSCLC). However, immunotherapy for …

Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of lung cancer
with the greatest heterogeneity and aggression. Inspite of recent years' achievements in …

Background Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer associated
with high mortality rates. We aimed to utilize single-cell multiomics analysis to identify the …

Background: The invasive potential is regarded as a pivotal determinant in the prognosis of
lung adenocarcinoma (LUAD). However, the cell ecology and spatial niche implicated in the …