Chitosan is an abundant natural cationic polysaccharide with excellent biodegradability,
bioadhesion, and biocompatibility. Chitosan is extensively researched for various particulate …

Diabetes mellitus is a chronic endocrine disease, affecting more than 400 million people
around the world. Patients with poorly controlled blood glucose levels are liable to suffer …

Over the last few decades, various natural polymers have been applied to the problem of
oral insulin delivery using advanced nanotechnology. Parenteral administration of insulin is …

We have developed self-assembled chitosan/insulin nanoparticles for successful oral insulin
delivery. The main purpose of our study is to prepare chitosan/insulin nanoparticles by self …

Insulin delivery by oral route would be ideal, but has no effect, due to the harsh conditions of
the gastrointestinal tract. Protection of insulin using encapsulation in self-assembled …

Despite advances in drug-delivery technologies, successful oral administration of protein
drugs remains an elusive challenge. When protein drugs are administered orally, they can …

Current therapy for diabetes mellitus through oral anti-diabetic drugs and subcutaneous
administration of insulin suffers from serious disadvantages, such as patient noncompliance …

Abstract Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an
ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan …

The development of efficient and bio-safe polymeric carriers for oral insulin delivery is a
major thrust in biomedical research. In this paper, dendronized chitosan (DCTS) is prepared …

Chitosan and chitosan derivative-based nanoparticles loaded with insulin were prepared by
self-assembly, via electrostatic interactions between the negatively charged drug and the …