Interleukin-2 (IL-2) possesses a strong stimulatory activity for activated T and NK cells and it
is an attractive molecule for immunotherapy. Nevertheless, extremely short half-life and …

Abstract Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical
metastatic cancers. However, its therapeutic concentrations do not last long due to its short …

Engineering polymer-based nano-systems have attracted many researchers owing to their
unique qualities like shape, size, porosity, mechanical strength, biocompatibility, and …

Effective induction of an antigen-specific cytotoxic T lymphocyte (CTL) immune response is
one of the key goals of cancer immunotherapy. We report the design and fabrication of …

Polymer conjugation to biologics is of key interest to the pharmaceutical industry for the
development of potent and long acting biotherapeutics, with poly (ethylene glycol)(PEG) …

IL‐12 is a pleiotropic cytokine, which shows an ideal applicant for tumor immunotherapy,
because of its features of creating an interconnection between innate (NK cells) and …

Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

CpG is a widely used adjuvant that enhances the cellular immune response by entering
antigen-presenting cells and binding with receptors. The traditional physical mixing of the …

The covalent attachment of polymers to the surface of proteins and nanoparticles has been
widely employed in the development of biomedical platforms capable of delaying or …

Recombinant therapeutic proteins have been considered as an efficient category of
medications used for the treatment of various diseases. Despite their effectiveness, there are …