Background: Inhibition of Toll-like receptors (TLRs) signaling has been established as a new
method for the development of anti-inflammatory drugs instead of NSAIDs (non-steroid anti …

Background: The non-steroidal anti-inflammatory drugs (NSAIDs) play crucial role in the
controlling of inflammatory diseases. Due to the vast side effects of NSAIDs, its use is limited …

Objective This research aimed to study the anti-inflammatory and immunomodulatory effects
of guluronic acid (G2013) on gene expression of TLR4, MyD88, SHIP1, SOCS1, NF-κB, and …

Context: Multiple sclerosis (MS) is an autoimmune and chronic inflammatory disease of
CNS. The α-L-guluronic acid (G2013) as novel NSAID with immunomodulatory effects has …

Aim: Rheumatoid arthritis (RA) is a prevalent inflammatory, autoimmune diseases
characterized by inflammation and destruction of joints. Disease-modifying anti-rheumatic …

Rheumatoid arthritis (RA) as a long-term autoimmune disease is characterized by pain,
swelling and joints destruction. The therapeutic efficacy of Guluronic acid (G2013)(patented …

Background Impaired expression and function of microRNAs (miRNAs) are involved in the
pathogenesis of many autoimmune and inflammatory diseases. Moreover, there is a close …

Background: Common variable immunodeficiency (CVID) is a primary immune disorder
associated with hypogammaglobulinemia, recurrent infections and autoimmune diseases …

Given multiple treatment strategies for prostate cancer, its mortality rate is still high;
therefore, novel treatment strategies seem necessary. G2013 or α‐L‐guluronic acid is a new …

The regulation of cytokines and pro‐inflammatory genes is an absolute essentiality to
combat inflammatory diseases. The present study investigated the effects of 4‐O …