Although studies have shown that administration of testosterone receptor antagonist,
flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune …

Objective: To determine the mechanism by which flutamide administration following trauma-
hemorrhage (TH) decreases cytokine production and hepatic injury under those conditions …

Drug‐induced liver injury is a growing concern for pharmaceutical companies and patients
because numerous drugs have been linked to hepatotoxicity and it is the most common …

Abstract Hemeoxygenase (HO)-1 induction following adverse circulatory conditions is
known to be protective, and precastrated males have less intestinal damage than sham …

Recent studies indicate beneficial effects of androgen depletion in male mice, before trauma-
hemorrahge on cell-mediated immunity following soft-tissue trauma and hemorrhagic shock …

BACKGROUND: Hepatic I/R injury is unavoidable in liver transplantation and surgery. This
remains a significant problem in surgical procedures. The purpose of this study was to …

Ischemia–reperfusion (I/R) injury after a liver transplant is a major cause of severe
complications that lead to graft dysfunction. Fucoidan, a complex of sulfated polysaccharides …

Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Flutamide is a widely used nonsteroidal antiandrogen for prostate cancer therapy, but its
clinical application is restricted by the concurrent liver injury. Increasing evidence suggests …

Liver disorders have been recognized as one major health concern. Fucoidan, a sulfated
polysaccharide extracted from the brown seaweed Fucus serratus, has previously been …