Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

Increasing evidence suggests that mechanics play a critical role in regulating brain function
at different scales. Downstream integration of mechanical inputs into biochemical signals …

Understanding the mechanical behavior of human brain is critical to interpret the role of
physical stimuli in both normal and pathological processes that occur in CNS tissue, such as …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Biological cells are well known to respond to a multitude of chemical signals. In the nervous
system, chemical signaling has been shown to be crucially involved in development, normal …

The regulation of synaptic strength forms the basis of learning and memory, and is a key
factor in understanding neuropathological processes that lead to cognitive decline and …

During brain development, progenitors generate successive waves of neurons that populate
distinct cerebral regions, where they settle and differentiate within layers or nuclei. While …

All cells are influenced by mechanical forces. In the brain, force-generating and load-
bearing proteins twist, turn, ratchet, flex, compress, expand and bend to mediate neuronal …

The regional mechanical properties of brain tissue are not only key in the context of brain
injury and its vulnerability towards mechanical loads, but also affect the behavior and …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …