Improving the measurement of serum thyroglobulin with mass spectrometry

AN Hoofnagle, MY Roth - The Journal of Clinical Endocrinology …, 2013 - academic.oup.com
Context: Serum thyroglobulin (Tg) measurements are central to the management of patients
treated for differentiated thyroid carcinoma. For decades, Tg measurements have relied on …

A novel mass spectrometry–based assay for the accurate measurement of thyroglobulin from patient samples containing antithyroglobulin autoantibodies

NJ Clarke, Y Zhang, RE Reitz - Journal of Investigative …, 2012 - journals.sagepub.com
Thyroid cancer is the most common endocrine cancer in the United States. The primary
treatment of thyroid cancer is partial or complete thyroidectomy in patients in whom the …

[HTML][HTML] A distributable LC-MS/MS method for the measurement of serum thyroglobulin

J Shi, WS Phipps, BY Owusu, CM Henderson… - Journal of Mass …, 2022 - Elsevier
Background Despite its clear advantages over immunoassay-based testing, the
measurement of serum thyroglobulin by mass spectrometry remains limited to a handful of …

Thyroglobulin measurement by highly sensitive assays: focus on laboratory challenges

L Giovanella, U Feldt-Rasmussen… - Clinical Chemistry and …, 2015 - degruyter.com
Differentiated thyroid cancer (DTC) is the most common endocrine cancer and its incidence
has increased in recent decades. The initial treatment consists of total thyroidectomy …

Measurement of thyroglobulin by liquid chromatography–tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies

MM Kushnir, AL Rockwood, WL Roberts… - Clinical …, 2013 - academic.oup.com
BACKGROUND Measurement of serum thyroglobulin (Tg) is used to monitor patients after
treatment for differentiated thyroid carcinoma (TC). Difficulty in using Tg as a biomarker of …

[HTML][HTML] More sensitivity is always better: measuring sub-clinical levels of serum thyroglobulin on a µLC–MS/MS system

CM Shuford, JS Johnson, JW Thompson… - Clinical Mass …, 2020 - Elsevier
Although liquid chromatography–tandem mass spectrometry (LC–MS/MS) assays for
thyroglobulin (Tg) are resistant to autoantibody (TgAb) interference, recent studies have …

Thyroglobulin liquid chromatography–tandem mass spectrometry has a low sensitivity for detecting structural disease in patients with antithyroglobulin antibodies

U Azmat, K Porter, L Senter, MD Ringel, F Nabhan - Thyroid, 2017 - liebertpub.com
Background: Thyroglobulin (Tg) measurement in patients with positive antithyroglobulin
antibodies (anti-TgAbs) is not reliable. Tg measurement using liquid chromatography …

Thyroglobulin measurement in the management of patients with differentiated thyroid cancer

A Algeciras-Schimnich - Critical Reviews in Clinical Laboratory …, 2018 - Taylor & Francis
The post-operative management of patients with differentiated thyroid carcinoma (DTC)
relies on serial measurements of serum thyroglobulin. Current methodologies for …

Thyroglobulin (Tg) testing revisited: Tg assays, TgAb assays, and correlation of results with clinical outcomes

BC Netzel, SKG Grebe… - The Journal of …, 2015 - academic.oup.com
Context: Measurement of thyroglobulin (Tg) by mass spectrometry (Tg-MS) is emerging as a
tool for accurate Tg quantification in patients with anti-Tg autoantibodies (TgAbs). Objective …

Highly sensitive thyroglobulin measurements in differentiated thyroid carcinoma management

L Giovanella - Clinical chemistry and laboratory medicine, 2008 - degruyter.com
Differentiated thyroid cancer is an infrequent disease with a generally good prognosis. The
initial treatment is total thyroidectomy coupled with ablation of thyroid remnants by iodine …