Type I interferons mediate pancreatic toxicities of PERK inhibition
Q Yu, B Zhao, J Gui, KV Katlinski… - Proceedings of the …, 2015 - National Acad Sciences
The great preclinical promise of the pancreatic endoplasmic reticulum kinase (PERK)
inhibitors in neurodegenerative disorders and cancers is marred by pancreatic injury and …
inhibitors in neurodegenerative disorders and cancers is marred by pancreatic injury and …
Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice
DT Hughes, M Halliday, HL Smith, NC Verity… - Science …, 2020 - science.org
Chronic activation of the unfolded protein response (UPR), notably the branch comprising
the kinase PERK and the translation initiation factor eIF2α, is a pathological feature of many …
the kinase PERK and the translation initiation factor eIF2α, is a pathological feature of many …
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
Activation of the PERK branch of the unfolded protein response (UPR) in response to protein
misfolding within the endoplasmic reticulum (ER) results in the transient repression of …
misfolding within the endoplasmic reticulum (ER) results in the transient repression of …
Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK
HP Harding, AF Zyryanova, D Ron - Journal of Biological Chemistry, 2012 - ASBMB
Loss-of-function mutations in EIF2AK3, encoding the pancreatic endoplasmic reticulum (ER)
kinase, PERK, are associated with dysfunction of the endocrine pancreas and diabetes …
kinase, PERK, are associated with dysfunction of the endocrine pancreas and diabetes …
Triggering ubiquitination of IFNAR 1 protects tissues from inflammatory injury
S Bhattacharya, KV Katlinski, M Reichert… - EMBO molecular …, 2014 - embopress.org
Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor
(consisting of IFNAR 1/IFNAR 2 chains) and inducing downstream signaling and gene …
(consisting of IFNAR 1/IFNAR 2 chains) and inducing downstream signaling and gene …
Bax Inhibitor-1 preserves pancreatic β-cell proteostasis by limiting proinsulin misfolding and programmed cell death
M Blanc, L Habbouche, P Xiao, C Lebeaupin… - Cell death & …, 2024 - nature.com
The prevalence of diabetes steadily increases worldwide mirroring the prevalence of
obesity. Endoplasmic reticulum (ER) stress is activated in diabetes and contributes to β-cell …
obesity. Endoplasmic reticulum (ER) stress is activated in diabetes and contributes to β-cell …
Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes
FR Papa - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Overwhelming of protein folding in the endoplasmic reticulum (ER)—referred to as “ER
stress”—activates a set of intracellular signaling pathways termed the unfolded protein …
stress”—activates a set of intracellular signaling pathways termed the unfolded protein …
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
K Iida, Y Li, BC McGrath, A Frank, DR Cavener - BMC cell biology, 2007 - Springer
Background Deficiency of the PERK eIF2α kinase in humans and mice results in postnatal
exocrine pancreatic atrophy as well as severe growth and metabolic anomalies in other …
exocrine pancreatic atrophy as well as severe growth and metabolic anomalies in other …
[HTML][HTML] Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes
R Ghosh, K Colon-Negron, FR Papa - Molecular metabolism, 2019 - Elsevier
Background Myriad challenges to the proper folding and structural maturation of secretory
pathway client proteins in the endoplasmic reticulum (ER)—a condition referred to as “ER …
pathway client proteins in the endoplasmic reticulum (ER)—a condition referred to as “ER …
Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse …
BM Tan, NW Zammit, AO Yam, R Slattery, SN Walters… - Diabetologia, 2013 - Springer
Aims/hypothesis For beta cells, contact with TNF-α triggers signalling cascades that
converge on pathways important for cell survival and inflammation, specifically nuclear …
converge on pathways important for cell survival and inflammation, specifically nuclear …