Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

M Duque, CA Lee-Kubli, Y Tufail, U Magaram… - Nature …, 2022 - nature.com
Ultrasound has been used to non-invasively manipulate neuronal functions in humans and
other animals. However, this approach is limited as it has been challenging to target specific …

Modulation of deep neural circuits with sonogenetics

Q Xian, Z Qiu, S Murugappan, S Kala… - Proceedings of the …, 2023 - National Acad Sciences
Noninvasive control of neuronal activity in the deep brain can be illuminating for probing
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …

Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification

S Yoo, DR Mittelstein, RC Hurt, J Lacroix… - Nature …, 2022 - nature.com
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …

Targeted neurostimulation in mouse brains with non-invasive ultrasound

Z Qiu, S Kala, J Guo, Q Xian, J Zhu, T Zhu, X Hou… - Cell reports, 2020 - cell.com
Recently developed brain stimulation techniques have significantly advanced our ability to
manipulate the brain's function. However, stimulating specific neurons in a desired region …

Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism

T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …

Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

TJ Manuel, J Kusunose, X Zhan, X Lv, E Kang… - Scientific Reports, 2020 - nature.com
Ultrasound is gaining traction as a neuromodulation method due to its ability to remotely and
non-invasively modulate neuronal activity with millimeter precision. However, there is little …

Ultrasound modulates ion channel currents

J Kubanek, J Shi, J Marsh, D Chen, C Deng, J Cui - Scientific reports, 2016 - nature.com
Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …

Ultrasound technologies for imaging and modulating neural activity

C Rabut, S Yoo, RC Hurt, Z Jin, H Li, H Guo, B Ling… - Neuron, 2020 - cell.com
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …

Ultrasonic neuromodulation via astrocytic TRPA1

SJ Oh, JM Lee, HB Kim, J Lee, S Han, JY Bae… - Current Biology, 2019 - cell.com
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain
stimulation technology for treating various neurological and psychiatric disorders. However …

Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein

YS Huang, CH Fan, N Hsu, NH Chiu, CY Wu… - Nano …, 2019 - ACS Publications
Biomolecules that respond to different external stimuli enable the remote control of
genetically modified cells. We report herein a sonogenetic approach that can manipulate …