Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels
Ultrasound has been used to non-invasively manipulate neuronal functions in humans and
other animals. However, this approach is limited as it has been challenging to target specific …
other animals. However, this approach is limited as it has been challenging to target specific …
Modulation of deep neural circuits with sonogenetics
Q Xian, Z Qiu, S Murugappan, S Kala… - Proceedings of the …, 2023 - National Acad Sciences
Noninvasive control of neuronal activity in the deep brain can be illuminating for probing
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …
brain function and treating dysfunctions. Here, we present a sonogenetic approach for …
Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …
neural activity in deep brain regions with high spatial precision and without chemical or …
Targeted neurostimulation in mouse brains with non-invasive ultrasound
Recently developed brain stimulation techniques have significantly advanced our ability to
manipulate the brain's function. However, stimulating specific neurons in a desired region …
manipulate the brain's function. However, stimulating specific neurons in a desired region …
Ultrasonic neuromodulation causes widespread cortical activation via an indirect auditory mechanism
T Sato, MG Shapiro, DY Tsao - Neuron, 2018 - cell.com
Ultrasound has received widespread attention as an emerging technology for targeted, non-
invasive neuromodulation based on its ability to evoke electrophysiological and motor …
invasive neuromodulation based on its ability to evoke electrophysiological and motor …
Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX
Ultrasound is gaining traction as a neuromodulation method due to its ability to remotely and
non-invasively modulate neuronal activity with millimeter precision. However, there is little …
non-invasively modulate neuronal activity with millimeter precision. However, there is little …
Ultrasound modulates ion channel currents
Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …
Ultrasound technologies for imaging and modulating neural activity
Visualizing and perturbing neural activity on a brain-wide scale in model animals and
humans is a major goal of neuroscience technology development. Established electrical and …
humans is a major goal of neuroscience technology development. Established electrical and …
Ultrasonic neuromodulation via astrocytic TRPA1
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain
stimulation technology for treating various neurological and psychiatric disorders. However …
stimulation technology for treating various neurological and psychiatric disorders. However …
Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein
YS Huang, CH Fan, N Hsu, NH Chiu, CY Wu… - Nano …, 2019 - ACS Publications
Biomolecules that respond to different external stimuli enable the remote control of
genetically modified cells. We report herein a sonogenetic approach that can manipulate …
genetically modified cells. We report herein a sonogenetic approach that can manipulate …