Stimulators and activators of soluble guanylate cyclase for urogenital disorders
Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and
urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions …
urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions …
Soluble guanylyl cyclase: physiological role as an NO receptor and the potential molecular target for therapeutic application
M Nakane - 2003 - degruyter.com
Nitric oxide (NO) activates soluble guanylyl cyclase, which results in an increased synthesis
of cyclic guanosine 3′, 5′-cyclic monophosphate (cGMP), smooth muscle relaxation and …
of cyclic guanosine 3′, 5′-cyclic monophosphate (cGMP), smooth muscle relaxation and …
Modulation of soluble guanylate cyclase for the treatment of erectile dysfunction
GF Lasker, EA Pankey, PJ Kadowitz - Physiology, 2013 - journals.physiology.org
Nitric oxide (NO) is the principal mediator of penile erection, and PDE-5 inhibitors are the
first-line agents used to treat erectile dysfunction (ED). When NO formation or bioavailability …
first-line agents used to treat erectile dysfunction (ED). When NO formation or bioavailability …
Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction
S Gur, PJ Kadowitz… - Current pharmaceutical …, 2010 - ingentaconnect.com
Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is the receptor that catalyzes the
formation of the intracellular messenger cyclic guanosine monophosphate (cGMP). Binding …
formation of the intracellular messenger cyclic guanosine monophosphate (cGMP). Binding …
Correlation of cellular expression with function of NO‐sensitive guanylyl cyclase in the murine lower urinary tract
B Lies, D Groneberg, A Friebe - The Journal of Physiology, 2013 - Wiley Online Library
Key points• Diseases of the lower urinary tract are associated with dysfunctions of cellular
mechanisms that regulate smooth muscle tone. Nitric oxide (NO) mediates relaxation of most …
mechanisms that regulate smooth muscle tone. Nitric oxide (NO) mediates relaxation of most …
Increased Cyclic Guanosine Monophosphate Synthesis and Calcium Entry Blockade Account for the Relaxant Activity of the Nitric Oxide–Independent Soluble …
HAF Toque, E Antunes, CE Teixeira, G De Nucci - Urology, 2008 - Elsevier
OBJECTIVES: To study the direct relaxant activity of 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-
pyrazolo [3, 4-b] pyridin-3-yl] pyrimidin-4-ylamine (BAY 41-2272) in the rabbit penile urethra …
pyrazolo [3, 4-b] pyridin-3-yl] pyrimidin-4-ylamine (BAY 41-2272) in the rabbit penile urethra …
Cyclic nucleotide metabolism including nitric oxide and phosphodiesterase-related targets in the lower urinary tract
S Ückert, MA Kuczyk - Urinary Tract, 2011 - Springer
The clinical data on the use of the orally active phosphodiesterase (PDE) type 5 inhibitors
sildenafil (VIAGRA™), vardenafil (LEVITRA™), and tadalafil (CIALIS™) for the treatment of …
sildenafil (VIAGRA™), vardenafil (LEVITRA™), and tadalafil (CIALIS™) for the treatment of …
Reduction of obstruction related bladder overactivity by the guanylyl cyclase modulators BAY 41‐2272 and BAY 60‐2770 alone or in combination with a …
C Füllhase, M Hennenberg, P Sandner… - Neurourology and …, 2015 - Wiley Online Library
Aims To assess the urodynamic effects of soluble guanylyl cyclase (sGC) stimulator, BAY 41‐
2272, and activator, BAY 60‐2770,(which both are able to induce cGMP synthesis even in …
2272, and activator, BAY 60‐2770,(which both are able to induce cGMP synthesis even in …
Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction
JD Brioni, M Nakane, GC Hsieh, RB Moreland… - International journal of …, 2002 - nature.com
Soluble guanylate cyclase (sGC) is an important enzyme in corpus cavernosum smooth
muscle cells as it is one of the regulators of the synthesis of cGMP. The efficacy of sildenafil …
muscle cells as it is one of the regulators of the synthesis of cGMP. The efficacy of sildenafil …
Structure and regulation of soluble guanylate cyclase
ER Derbyshire, MA Marletta - Annual review of biochemistry, 2012 - annualreviews.org
Nitric oxide (NO) is an essential signaling molecule in biological systems. In mammals, the
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …
diatomic gas is critical to the cyclic guanosine monophosphate (cGMP) pathway as it …