[HTML][HTML] miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

MT Di Martino, M Arbitrio, D Caracciolo… - … Therapy-Nucleic Acids, 2022 - cell.com
Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …

[HTML][HTML] Potential value of miR-221/222 as diagnostic, prognostic, and therapeutic biomarkers for diseases

J Song, Y Ouyang, J Che, X Li, Y Zhao, K Yang… - Frontiers in …, 2017 - frontiersin.org
microRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base
pairing with their target messenger RNAs. Dysregulation of miRNAs is involved in the …

Mir-221/222 are promising targets for innovative anticancer therapy

MT Di Martino, M Rossi, D Caracciolo… - Expert Opinion on …, 2016 - Taylor & Francis
Introduction: MicroRNAs (miRNAs) are key non-coding RNA post-transcriptional regulators
of messenger RNAs (mRNAs), and are deeply dysregulated in human cancer. A rising body …

[HTML][HTML] A myriad of roles of miR-25 in health and disease

M Sárközy, Z Kahán, T Csont - Oncotarget, 2018 - ncbi.nlm.nih.gov
Small non-coding RNAs including microRNAs (miRNAs) have been recently recognized as
important regulators of gene expression. MicroRNAs play myriads of roles in physiological …

[HTML][HTML] Prognostic role of miR-221 and miR-222 expression in cancer patients: a systematic review and meta-analysis

G Ravegnini, S Cargnin, G Sammarini, F Zanotti… - Cancers, 2019 - mdpi.com
Background: A wealth of evidence has shown that microRNAs (miRNAs) can modulate
specific genes, increasing our knowledge on the fine-tuning regulation of protein …

miR221/222 in cancer: their role in tumor progression and response to therapy

M Garofalo, C Quintavalle, G Romano… - Current molecular …, 2012 - ingentaconnect.com
miRNAs are small non-coding RNAs of~ 24 nt that can block mRNA translation and/or
negatively regulate its stability. There is a large body of evidence that dysregulation of …

[HTML][HTML] MiR-21 in the cancers of the digestive system and its potential role as a diagnostic, predictive, and therapeutic biomarker

HT Nguyen, SEO Kacimi, TL Nguyen, KH Suman… - Biology, 2021 - mdpi.com
Simple Summary MicroRNAs are small, non-coding RNA molecules that can regulate the
expression of various cancer-related genes and thereby contribute to tumorigenesis and …

[HTML][HTML] Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer

J Wang, Y Li, M Ding, H Zhang… - … Journal of Oncology, 2017 - spandidos-publications.com
Abstract miRNAs (microRNAs) have been validated to play fateful roles in the occurrence
and development of cancers by post-transcriptionally targeting 3'-untranslated regions of the …

[HTML][HTML] MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

M Faramin Lashkarian, N Hashemipour… - Cancer Cell …, 2023 - Springer
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the
expression of target genes post-transcriptionally and interact with mRNA-coding genes …

MiR-211 plays a dual role in cancer development: from tumor suppressor to tumor enhancer

H Shirvani, J Ghanavi, A Aliabadi, F Mousavinasab… - Cellular …, 2023 - Elsevier
Cancer is a general term for more than 100 unique malignancies in different organs of the
body. Each cancer type and subtype has its own unique genetic, epigenetic, and cellular …