Alternative splicing is regulated by multiple RNA-binding proteins and influences the
expression of most eukaryotic genes. However, the role of this process in human disease …

Cancer is a complex disease that involves aberrant gene expression regulation.
Discriminating the modified expression patterns driving tumor biology from the many that …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

Understanding how RNA binding proteins control the splicing code is fundamental to human
biology and disease. Here, we present a comprehensive study to elucidate how …

Background Alternative pre-mRNA splicing (AS) plays a central role in generating complex
proteomes and influences development and disease. However, the regulation and etiology …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Background Somatic mutations affecting components of the RNA splicing machinery occur
with high frequencies across many tumor types. These mutations give rise to distinct …