The neuropathological diagnosis of Alzheimer's disease

MA DeTure, DW Dickson - Molecular neurodegeneration, 2019 - Springer
Alzheimer's disease is a progressive neurodegenerative disease most often associated with
memory deficits and cognitive decline, although less common clinical presentations are …

Neuropathological assessment of the Alzheimer spectrum

KA Jellinger - Journal of Neural Transmission, 2020 - Springer
Alzheimer disease (AD), the most common form of dementia globally, classically defined a
clinicopathological entity, is a heterogenous disorder with various pathobiological subtypes …

Core biological marker candidates of Alzheimer's disease–perspectives for diagnosis, prediction of outcome and reflection of biological activity

H Hampel, A Mitchell, K Blennow, RA Frank… - Journal of neural …, 2004 - Springer
Alzheimer's disease (AD) is a complex neurodegenerative dementing illness. Over the past
few years, however, remarkable advances have taken place in understanding both the …

Advances in deep neuropathological phenotyping of Alzheimer disease: past, present, and future

MN Shakir, BN Dugger - Journal of Neuropathology & …, 2022 - academic.oup.com
Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the
presence of neurofibrillary tangles and amyloid beta (Aβ) plaques in the brain. The disease …

Biomarkers in Alzheimer's disease: past, present and future

K Gustaw-Rothenberg, A Lerner, DJ Bonda… - Biomarkers in …, 2010 - Taylor & Francis
Epidemiological and molecular studies suggest that Alzheimer's disease (AD) has multiple
etiologies including genetic mutations, genetic variations affecting susceptibility and …

Neuropathology of Alzheimer's disease: a critical update

KA Jellinger, C Bancher - Alzheimer's Disease—From Basic Research to …, 1998 - Springer
The unequivocal diagnosis of Alzheimer's disease (AD) rests on histopathological evidence
at brain autopsy or biopsy. The morphology of AD includes cerebral atrophy, deposition of …

Recent progress in Alzheimer's disease research, part 3: diagnosis and treatment

FT Hane, M Robinson, BY Lee, O Bai… - Journal of …, 2017 - content.iospress.com
The field of Alzheimer's disease (AD) research has grown exponentially over the past few
decades, especially since the isolation and identification of amyloid-β from postmortem …

Aging and Alzheimer's disease pathology

R Sengoku - Neuropathology, 2020 - Wiley Online Library
The number of people with dementia worldwide is predicted to increase to 131.5 million by
2050. When studying dementia, understanding the basis of the neuropathological …

Increasing precision of clinical diagnosis of Alzheimer's disease using a combined algorithm incorporating clinical and novel biomarker data

MN Sabbagh, LF Lue, D Fayard, J Shi - Neurology and therapy, 2017 - Springer
Establishing the in vivo diagnosis of Alzheimer's disease (AD) or other dementias relies on
clinical criteria; however, the accuracy of these criteria can be limited. The diagnostic …

Alzheimer disease: current concepts and emerging diagnostic and therapeutic strategies

CM Clark, JHT Karlawish - Annals of internal medicine, 2003 - acpjournals.org
Alzheimer disease is a complex neurodegenerative dementing illness. It has become a
major public health problem because of its increasing prevalence, long duration, high cost of …