This study tests the hypothesis that the efficacy of hypothermia as a cardiacprotective agent
can be increased by adding the slow channel-blocking agent, nifedipine. Isolated …

In a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest the potential
additive protective effects of hypothermia and chemical cardioplegia have been …

In clinical use cardioplegia is usually combined with local cardiac hypothermia, whose
powerful protective effects make it difficult to assess the contributions made by the …

This experimental study was undertaken to evaluate the hypothesis that cardioplegic arrest
at 37° C is superior to 10° C cardioplegic arrest in the myocardial protection of an acutely …

Nifedipine, a slow-channel calcium blocker, is thought to provide useful myocardial
protection during prolonged total ischemia and reperfusion. An isolated, isovolumic, feline …

This report summarizes five years of laboratory investigations and the initial six-month
clinical experience with a calcium antagonist, nifedipine, added to a cold hyperkalcmic …

Sixty-four dogs were placed on normothermic total cardiopulmonary bypass, and global
ischemia was induced for 1 hour during which continuous infusions (240 ml per hour)(N …

To assess the effects of moderate potassium cardioplegia (37 mEq/l KCl) on the severity of
myocardial ischemia during arrest and on post arrest ventricular function, 32 isolated …

Hypothermia combined with pharmacologic cardioplegia protects the globally ischemic adult
heart, but this benefit may not extend to children; poor postischemic recovery of function and …

BACKGROUND: Hypothermia during ischemia has been shown to reduce myocardial
reperfusion injury. We sought to establish the cardioprotective effect of very mild total-body …