Abstract Cyclin-dependent kinase 6 (CDK6) participates in numerous signalling pathways
and regulates various physiological processes. Due to its unique structural features and …

The duality of function (cell cycle regulation and gene transcription) of cyclin-dependent
kinase 7 (CDK7) makes it an attractive oncology target and the discovery of CDK7 inhibitors …

Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in
the progression of different types of cancers. We performed in silico and in vitro screening of …

Abstract Cyclin-dependent kinase 9 (CDK9) is a transcription-associated protein involved in
controlling the cell cycle and is often deregulated in stress conditions. CDK9 is being studied …

Cyclin-dependent kinase 2 (CDK2) is an essential protein kinase involved in the cell cycle
regulation. The abnormal activity of CDK2 is associated with cancer progression and …

Abstract Cyclin dependent kinase 7 (CDK7) is an attractive target in tumor indications via
regulating both cell cycle and transcription. Here, SHR5428 was discovered as a selective …

Cancer is one of the major causes of global deaths and needs immediate therapeutic
development. So far, several strategies have been undertaken to prevent cancer, including …

The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and
RNA polymerase-based transcription. Overexpression of this kinase is linked with various …

Abstract Cyclin‐dependent kinase 6 (CDK6) is a member of serine/threonine kinase family,
and its overexpression is associated with cancer development. Thus, it is considered as a …

Excessive cell proliferation due to cell cycle disorders is one of the hallmarks of breast
cancer. Cyclin-dependent kinases (CDKs), which are involved in the transition of the cell …