Chemoenzymatic synthesis of glycosaminoglycans
X Zhang, L Lin, H Huang… - Accounts of Chemical …, 2019 - ACS Publications
Conspectus Glycosaminoglycans (GAGs) are a family of structurally complex
heteropolysaccharides composed of alternating hexosamine and uronic acid or galatose …
heteropolysaccharides composed of alternating hexosamine and uronic acid or galatose …
Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains
Glycosaminoglycans (GAGs) are complex polysaccharides composed of hexosamine-
containing disaccharide repeating units. The three most studied classes of GAGs …
containing disaccharide repeating units. The three most studied classes of GAGs …
Recent chemical and enzymatic approaches to the synthesis of glycosaminoglycan oligosaccharides
NA Karst, RJ Linhardt - Current medicinal chemistry, 2003 - ingentaconnect.com
Glycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are
an important class of therapeutic agents and investigational drug candidates. Heparin has …
an important class of therapeutic agents and investigational drug candidates. Heparin has …
Bio-based strategies for producing glycosaminoglycans and their oligosaccharides
Z Kang, Z Zhou, Y Wang, H Huang, G Du, J Chen - Trends in biotechnology, 2018 - cell.com
Glycosaminoglycans (GAGs) and their oligosaccharides have attracted extensive attention
because of their wide applications in cosmetics, health, and clinical treatment of, for …
because of their wide applications in cosmetics, health, and clinical treatment of, for …
Enzymes in the synthesis of glycoconjugates
RM Schmaltz, SR Hanson, CH Wong - Chemical reviews, 2011 - ACS Publications
Aims This review is intended to update our previous discussion on the chemoenzymatic
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
synthesis of carbohydrates and glycoconjugates,(1) with new emphasis placed on …
Current state on the enzymatic synthesis of glycosaminoglycans
J Gottschalk, L Elling - Current opinion in chemical biology, 2021 - Elsevier
Glycosaminoglycans (GAGs) are linear anionic polysaccharides, and most of them show a
specific sulfation pattern. GAGs have been studied for decades, and still, new biological …
specific sulfation pattern. GAGs have been studied for decades, and still, new biological …
Chemical synthesis of glycosaminoglycans
M Mende, C Bednarek, M Wawryszyn, P Sauter… - Chemical …, 2016 - ACS Publications
Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …
essential biological cell processes, as well as in many courses of diseases. Because of the …
Engineering of routes to heparin and related polysaccharides
U Bhaskar, E Sterner, AM Hickey, A Onishi… - Applied microbiology …, 2012 - Springer
Anticoagulant heparin has been shown to possess important biological functions that vary
according to its fine structure. Variability within heparin's structure occurs owing to its …
according to its fine structure. Variability within heparin's structure occurs owing to its …
Chemoenzymatic synthesis of heparan sulfate and heparin oligosaccharides and NMR analysis: paving the way to a diverse library for glycobiologists
X Zhang, V Pagadala, HM Jester, AM Lim, TQ Pham… - Chemical …, 2017 - pubs.rsc.org
Heparan sulfate (HS) is a member of the glycosaminoglycans (GAG) family that plays
essential roles in biological processes from animal sources. Heparin, a highly sulfated form …
essential roles in biological processes from animal sources. Heparin, a highly sulfated form …
Making the longest sugars: a chemical synthesis of heparin-related [4] n oligosaccharides from 16-mer to 40-mer
The chemical synthesis of long oligosaccharides remains a major challenge. In particular,
the synthesis of glycosaminoglycan (GAG) oligosaccharides belonging to the heparin and …
the synthesis of glycosaminoglycan (GAG) oligosaccharides belonging to the heparin and …