Human immunodeficiency virus (HIV) infection can be controlled by anti-retroviral therapy.
Suppressing viral replication relies on life-long medication, but anti-retroviral therapy is not …

Background The main approach to treat HIV-1 infection is combination antiretroviral therapy
(cART). Although cART is effective in reducing HIV-1 viral load and controlling disease …

Hematopoietic stem-cell (HSC) transplantation using a donor with a homozygous mutation
in the HIV co-receptor CCR5 (CCR5Δ32/Δ32) holds great promise as a cure for HIV-1 …

Acquired immunodeficiency syndrome (AIDS) is a life-threatening disorder caused by
infection of individuals with the human immunodeficiency virus (HIV). Entry of HIV-1 into …

Background The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection.
People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 …

Genome editing via CRISPR/Cas9 has become an efficient and reliable way to make
precise, targeted changes to the genome of living cells. CXCR4 is a co-receptor for the …

Highlights•Homozygous CCR5Δ32/Δ32 mutation renders cells deficient of CCR5 surface
expression.•Naturally CCR5-deficient immune cells are resistant to infection with CCR5 …

Transplanting HIV-1 positive patients with hematopoietic stem cells homozygous for a 32 bp
deletion in the chemokine receptor type 5 (CCR5) gene resulted in a loss of detectable HIV …

The goal of gene therapy is to introduce foreign genes into human target cells in a certain
way to correct or compensate diseases caused by defective or abnormal genes. Therefore …

Transplantation of hematopoietic stem cells (HSCs) with a naturally occurring CCR5
mutation confers a loss of detectable HIV-1 in the patient, making ablation of the CCR5 gene …