Introduction of gelatin microspheres into an injectable calcium phosphate cement

W Habraken, LT De Jonge, JGC Wolke… - … Research Part A: An …, 2008 - Wiley Online Library
For tissue engineered bone constructs, calcium phosphate cement (CPC) has a high
potential as scaffold material because of its biocompatibility and osteoconductivity. However …

Porcine gelatin microsphere/calcium phosphate cement composites: An in vitro degradation study

WJEM Habraken, JGC Wolke… - Journal of Biomedical …, 2009 - Wiley Online Library
Scaffolds for bone tissue engineering preferably should be mechanically stable,
osteoconductive, biodegradable and porous. To comply with these characteristics, calcium …

In vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres

W Habraken, OC Boerman, JGC Wolke… - … Research Part A: An …, 2009 - Wiley Online Library
To improve the in vivo resorption of an injectable calcium phosphate cement (CPC) for bone
tissue engineering purposes, in previous experiments macroporosity was introduced by the …

Evaluation of an orthotopically implanted calcium phosphate cement containing gelatin microparticles

DP Link, J van den Dolder… - … Research Part A: An …, 2009 - Wiley Online Library
This study focused on the degradation properties of gelatin microparticles incorporated in
calcium phosphate (CaP) cement and the subsequent effect of these composites on bone …

Injectable calcium phosphate cement with PLGA, gelatin and PTMC microspheres in a rabbit femoral defect

H Liao, XF Walboomers, WJEM Habraken, Z Zhang… - Acta biomaterialia, 2011 - Elsevier
In this study, we investigated the in vivo degradation properties and tissue response towards
injectable calcium phosphate cement (CPC) with no further addition, or calcium phosphate …

In vivo degradation of calcium phosphate cement incorporated into biodegradable microspheres

W Habraken, HB Liao, Z Zhang, JGC Wolke… - Acta biomaterialia, 2010 - Elsevier
In this study we have investigated the influence of the mechanism of microsphere
degradation or erosion on the in vivo degradation of microsphere/calcium phosphate …

Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration

D Meng, L Dong, Y Wen, Q Xie - Materials Science and Engineering: C, 2015 - Elsevier
Calcium phosphate cements (CPCs) have been widely used as bone graft substitutes.
However, the undesirable osteoinductivity and slow degradability of CPCs greatly hamper …

Improved injectability and in vitro degradation of a calcium phosphate cement containing poly (lactide-co-glycolide) microspheres

X Qi, J Ye, Y Wang - Acta biomaterialia, 2008 - Elsevier
An injectable calcium phosphate cement (CPC) containing 30wt.% poly (lactide-co-
glycolide)(PLGA) microspheres was developed in the present study. Sodium citrate solution …

PLGA microsphere/calcium phosphate cement composites for tissue engineering: in vitro release and degradation characteristics

W Habraken, JGC Wolke, AG Mikos… - Journal of Biomaterials …, 2008 - Taylor & Francis
Bone cements with biodegradable poly (lactic-co-glycolic acid)(PLGA) microspheres have
already been proven to provide a macroporous calcium phosphate cement (CPC) during in …

Injectable PLGA microsphere/calcium phosphate cements: physical properties and degradation characteristics

W Habraken, JGC Wolke, AG Mikos… - Journal of Biomaterials …, 2006 - Taylor & Francis
Calcium phosphate (CaP) cements show an excellent biocompatibility and often have a high
mechanical strength, but in general degrade relatively slow. To increase degradation rates …