Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome

L Di, C Zha, Y Liu - Platelets, 2023 - Taylor & Francis
Platelet microparticles (PMPs) are vesicles that are released by platelets into the
extracellular space and play a role in antiphospholipid antibody syndromes. PMPs have …

Anti‑β2GPI/β2GPI induces neutrophil pyroptosis and thereby enhances ICAM‑1 and IL‑8 expression in endothelial cells

J Luo, M Zhang, Z Wang, L Yan… - … journal of molecular …, 2022 - spandidos-publications.com
Abstract Anti‑β 2‑glycoprotein I (anti‑β 2 GPI) is an anti‑phospholipid antibody that
specifically binds to β 2 GPI. There is growing evidence that this autoantibody is closely …

Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation

SC Lo, CY Hung, DT Lin, HC Peng… - Journal of biomedical …, 2006 - Springer
Platelet microparticles (MPs) are membrane vesicles shed by platelets after activation, and
carry antigens characteristic of intact platelets, such as glycoprotein (GP) IIb/IIIa, GPIb and P …

Platelets activated by the anti-β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells

Y Zhang, W Zhang, C Zha, Y Liu - Cellular & Molecular Biology Letters, 2018 - Springer
Background Patients with anti-β2GPI antibodies display significantly higher platelet
activation/aggregation and vascular endothelial cell damage. The mechanism underlying …

Development and assessment of enzyme immunoassay for platelet-derived microparticles

K Osumi, Y Ozeki, S Saito, Y Nagamura… - Thrombosis and …, 2001 - thieme-connect.com
Platelet-derived microparticles (PMPs) are released from platelets through the platelet
activation by high shear stress, collagen, or calcium ionophore (A23187). PMPs are …

Microparticles: an alternative explanation to the behavior of vascular antiphospholipid syndrome

D Álvarez, C Rúa - Seminars in Thrombosis and Hemostasis, 2021 - thieme-connect.com
Antiphospholipid syndrome is an autoimmune disease characterized by the persistent
presence of antiphospholipid antibodies, along with occurrence of vascular thrombosis and …

Function and clinical significance of platelet-derived microparticles

S Nomura - International journal of hematology, 2001 - Springer
Microparticles released from platelets (PMPs) may play a role in the normal hemostatic
response to vascular injury because they demonstrate prothrombinase activity. PMPs were …

Platelet-derived microparticles from recurrent miscarriage associated with antiphospholipid antibody syndrome influence behaviours of trophoblast and endothelial …

Q Zhou, Y Lian, Y Zhang, L Li, H Li… - Molecular Human …, 2019 - academic.oup.com
Platelet-derived microparticles (PMPs) are a type of microparticle budding from platelets
undergoing activation or apoptosis in many autoimmune diseases, including …

Platelet microparticles: detection and assessment of their paradoxical functional roles in disease and regenerative medicine

T Burnouf, HA Goubran, ML Chou, D Devos… - Blood reviews, 2014 - Elsevier
There is increasing research on and clinical interest in the physiological role played by
platelet microparticles (PMPs). PMPs are 0.1–1-μm fragments shed from plasma …

Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses

O Morel, N Morel, JM Freyssinet, F Toti - Platelets, 2008 - Taylor & Francis
Described 40 years ago as cell dust, microparticles (MPs) are now considered a key
component in the haemostatic response. Owing to their plasma membrane reactivity …