The immune system in Cushing's syndrome

V Hasenmajer, E Sbardella, F Sciarra… - Trends in endocrinology …, 2020 - cell.com
Cushing's syndrome (CS), or chronic hypercortisolism, induces a variety of alterations in the
immune system, often leading to severe clinical complications such as sepsis and …

Cushing's syndrome: update on signs, symptoms and biochemical screening

LK Nieman - European journal of endocrinology, 2015 - academic.oup.com
Endogenous pathologic hypercortisolism, or Cushing's syndrome, is associated with poor
quality of life, morbidity, and increased mortality. Early diagnosis may mitigate against this …

Complications of Cushing's syndrome: state of the art

R Pivonello, AM Isidori, MC De Martino… - The lancet Diabetes & …, 2016 - thelancet.com
Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and
excessive secretion of cortisol. The syndrome is associated with increased mortality and …

Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome

MJ Barahona, N Sucunza, E Resmini… - The Journal of …, 2009 - academic.oup.com
Objective: Although increased central fat mass is characteristic of active Cushing's syndrome
(CS), little is known about body composition and secretion of adipokines after long-term …

Metabolic and cardiovascular outcomes in patients with Cushing's syndrome of different aetiologies during active disease and 1 year after remission

R Giordano, A Picu, E Marinazzo… - Clinical …, 2011 - Wiley Online Library
Objective Cushing's syndrome is associated with several comorbidities responsible for the
increased cardiovascular risk, not only during the active phase but also after disease …

Metabolic comorbidities in Cushing's syndrome

F Ferrau, M Korbonits - European Journal of Endocrinology, 2015 - academic.oup.com
Cushing's syndrome (CS) patients have increased mortality primarily due to cardiovascular
events induced by glucocorticoid (GC) excess-related severe metabolic changes. Glucose …

Glucocorticoids and immune function

GAW Rook - Best Practice & Research Clinical Endocrinology & …, 1999 - Elsevier
The prevailing notion has been that cytokines such as interleukin-1 released from sites of
inflammation cross the blood–brain barrier and drive the hypothalamo–pituitary–adrenal …

Multisystem morbidity and mortality in Cushing's syndrome: a cohort study

OM Dekkers, E Horváth-Puhó… - The Journal of …, 2013 - academic.oup.com
Context: Cushing's syndrome (CS) is associated with hypercoagulability, insulin resistance,
hypertension, bone loss, and immunosuppression. To date, no adequately large cohort …

Comorbidities in Cushing's disease

ST Sharma, LK Nieman, RA Feelders - Pituitary, 2015 - Springer
Introduction Cushing's disease is a rare disorder characterized by overproduction of ACTH
from a pituitary adenoma leading to hypercortisolemia that in turn leads to increased …

The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications

AM Isidori, C Graziadio, RM Paragliola… - Journal of …, 2015 - journals.lww.com
Cushing's syndrome is associated with increased mortality, mainly due to cardiovascular
complications, which are sustained by the common development of systemic arterial …