The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

The amyloid-β (Aβ) peptide has long been considered to be the driving force behind
Alzheimer's disease (AD). However, clinical trials that have successfully reduced Aβ burden …

Background The amyloid β-protein (Aβ) is believed to be the key mediator of Alzheimer's
disease (AD) pathology. Aβ is most often characterized as an incidental catabolic byproduct …

Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …

The Aβ peptides causally associated with Alzheimer disease have been seen as seemingly
purposeless species produced by intramembrane cleavage under both physiological and …

Cerebral aggregation of amyloid-β (Aβ) is thought to play a major role in the etiology of
Alzheimer's disease. Environmental influences, including chronic bacterial or viral infections …

Despite the enormous literature documenting the importance of amyloid beta (Aβ) protein in
Alzheimer's disease, we do not know how Aβ aggregation is initiated and why it has its …

Amyloid-β (Aβ) peptides are the main components of the plaques found in the brains of
patients with Alzheimer's disease. However, Aβ peptides are also detectable in secretory …

Alzheimer's disease (AD) is a chronic neurodegenerative disease associated with the
overproduction and accumulation of amyloid-β peptide and hyperphosphorylation of tau …

Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …