Carboline Regioisomers Based on Unified Synthetic Approaches

ASM Arshad, MN Mordi - Advanced Synthesis & Catalysis, 2023 - Wiley Online Library
Carbolines are a prominent class of tricyclic alkaloids omnipresent in natural products and
bioactive compounds. Four different carboline regioisomers are known (α‐, β‐, γ‐, and δ …

Synthesis Strategies for α‐, β‐, γ‐and δ‐Carbolines

H Zhang, RH Zhang, LX Wang, YJ Li… - Asian Journal of …, 2021 - Wiley Online Library
Carbolines are widely present in various natural products and biological molecules.
Numerous studies have shown the broad biological activities of these heterocyclic motifs …

[HTML][HTML] Recent advances in the synthesis of β-carboline alkaloids

T Szabó, B Volk, M Milen - Molecules, 2021 - mdpi.com
β-Carboline alkaloids are a remarkable family of natural and synthetic indole-containing
heterocyclic compounds and they are widely distributed in nature. Recently, these alkaloids …

Novel chemistry of β-carbolines. Expedient synthesis of polycyclic scaffolds

A Gonzalez-Gomez, G Domínguez, J Perez-Castells - Tetrahedron, 2009 - Elsevier
Functionalization of β-carbolines is a challenge as numerous natural alkaloids with different
biological activities present this heterocycle. The RCM is used herein with allyl-, vinyl …

1 (3)‐Formyl‐β‐carbolines: Potential Aldo‐X Precursors for the Synthesis of β‐Carboline‐Based Molecular Architectures

N Devi, S Kumar, SK Pandey… - Asian Journal of Organic …, 2018 - Wiley Online Library
Abstract β‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of
medicinal properties and is found in several commercial drugs, such as tadalafil …

Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines

A Banerjee, S Kundu, A Bhattacharyya… - Organic Chemistry …, 2021 - pubs.rsc.org
Nitrogen-containing π-excessive aromatic heterocycles, in particular, carbazoles,
indolocarbazoles, benzocarbazoles, and carbolines have been considered the fundamental …

Synthesis of β-carbolines (microreview)

M Milen, P Ábrányi-Balogh - Chemistry of Heterocyclic Compounds, 2016 - Springer
β-Carbolines are an important class of heterocyclic compounds because of their broad
spectrum of biological profiles. Consequently, many methodologies have been described to …

Synthesis of Functionalized 4-Hydroxy Carbazoles and Carbazole Alkaloids via Ring Expansion of Indole Cyclopentanone

X Pan, B Dong, Y Wu, B Gao… - The Journal of Organic …, 2024 - ACS Publications
The exploration of a ring expansion reaction from indole cyclopentanone to generate a
range of diversely functionalized 4-hydroxyl carbazole frameworks, representing the core …

Cascade benzannulation approach for the syntheses of lipocarbazoles, carbazomycins, and related alkaloids

A Banerjee, S Saha, MS Maji - The Journal of Organic Chemistry, 2022 - ACS Publications
Herein, a state-of-the-art one-pot cascade benzannulation technique for the efficacious
synthesis of valuable 3-hydroxy-2-methyl carbazoles, a linchpin of more than 25 carbazole …

Recent developments on synthesis strategies, SAR studies and biological activities of β-carboline derivatives–an update

R Abinaya, S Srinath, S Soundarya, R Sridhar… - Journal of Molecular …, 2022 - Elsevier
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …