Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor
hypoxia and a rational target to overcome it have been sought to realize personalized …

Serine peptidase inhibitor Kazal type-1 (SPINK1), a trypsin kinase inhibitor, is known to be
associated with inflammation and pathogenesis. The aim in this study was to demonstrate …

Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal
cells in the tumour microenvironment (TME), inducing a senescence-associated secretory …

Serine Peptidase Inhibitor Kazal Type 1 (SPINK1) is a secreted protein known as a protease
inhibitor of trypsin in the pancreas. However, emerging evidence shows its function in …

Serine protease inhibitor Kazal‑type 1 (SPINK1) is a trypsin kinase inhibitor, which is
involved in the development of inflammation, cell proliferation and cancer development and …

Drug resistance has always been the main problem in osteosarcoma treatment, and hypoxia
seems to be one of the many causes for drug resistance. Therefore, in this study, we …

BACKGROUND Tumor-associated trypsin inhibitor (TATI) was originally isolated from the
urine of a patient with ovarian cancer. It was later shown to be produced by many other …

Background and purpose Krüpple-like factor 10 (Klf10), an early response gene of TGFβ,
was reported to be a prognostic biomarker for pancreatic cancer survival. The role of Klf10 in …

Transcriptional changes in response to hypoxia are regulated in part through mitogen-
activated protein (MAP) kinase signaling to activator protein 1 (AP-1), and thus contribute to …

Background SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is
abundantly expressed in human goblet cells. The clinical significance of SPINK4 in …