Unique structural features characterize the P2X7 receptor with respect to other P2X family
members. Dual gating by eATP and regulated expression of P2X7 can imprint distinct …

The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological
ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2. 2-dependent ADP …

The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is
expressed by several cells of the immune system. P2X7 is best known for its …

Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response
via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space …

Extracellular ATP activates the P2X7 receptor, leading to inflammasome activation and
release of pro‐inflammatory cytokines in monocytes. However, a detailed analysis of P2X7 …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

The P2X 7 receptor is an ATP-gated cation channel that is widely expressed in cells of the
immune system. Signal transduction is accompanied by fast influx of Ca 2+ and Na+, and …

Lupus is a chronic inflammatory autoimmune disease influenced by multiple genetic loci
including Fas Ligand (FasL) and P2X7 receptor (P2X7R). The Fas/Fas Ligand apoptotic …

The ATP-activated P2X7 receptor channel is involved in immune function and inflammatory
pain and represents an important drug target. Here we describe a new P2X7 splice variant …

Abstract The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor
family. It is distributed in various tissues of the human body and is involved in regulating the …