Collagens are the most abundant fibrous protein in the human body and constitute the main
structural element of the extracellular matrix. It provides mechanical and physiological …

Widespread use of pancreatic islet transplantation for treatment of type 1 diabetes (T1D) is
currently limited by requirements for long-term immunosuppression, limited donor supply …

Extracellular matrix (ECM) molecules have several functions in pancreatic islets, including
provision of mechanical support and prevention of cytotoxicity during inflammation. During …

Immunoisolation of pancreatic-islets in alginate-microcapsules is applied to treat diabetes.
However, long-term islet function is limited, which might be due to damaged and lack of …

Islet transplantation represents a viable treatment for type 1 diabetes. However, due to loss
of substantial mass of islets early after transplantation, islets from two or more donors are …

In the pancreas, extracellular matrix (ECM) components play an import role in providing
mechanical and physiological support, and also contribute to the function of islets. These …

Intrahepatic islet transplantation is a promising therapy for treatment of type 1 diabetes.
During islet isolation, collagenase is used to extract islets from the pancreas, leading to loss …

Immuno-isolation of islets has the potential to enable the replacement of pancreatic function
in diabetic patients. However, host response to the encapsulated islets frequently leads to …

Islet transplantation provides a promising approach for treatment of type 1 diabetes mellitus.
Amyloid formation and loss of extracellular matrix are two nonimmune factors contributing to …

In this study, we suggest in situ islet spheroid formation and encapsulation on a single
platform without replating as a method for producing mono-disperse spheroids and …