Although cardiac action potential (AP) generation and propagation have traditionally been
attributed exclusively to cardiomyocytes (CM), other cell types in the heart are also capable …

Cardiac myocytes and fibroblasts form extensive networks in the heart, with numerous
anatomical contacts between cells. Fibroblasts, obligatory components of the extracellular …

The spread of cardiac excitation, whether conceptually based on viewing the heart as an
electrical syncytium or as a discontinuously conducting structure, is conventionally …

The heart is comprised of a syncytium of cardiac myocytes (CM) and surrounding
nonmyocytes, the majority of which are cardiac fibroblasts (CF). CM and CF are highly …

Cardiac arrhythmias are a very important clinical problem. Ventricular tachyarrhythmias
(VTs) are a leading cause of death in the developed world, 1 and atrial fibrillation (AF) is a …

Abstract Aims Macrophages (MΦ), known for immunological roles, such as phagocytosis
and antigen presentation, have been found to electrotonically couple to cardiomyocytes …

Cardiac electrophysiology is a complex system established by a plethora of inward and
outward ion currents in cardiomyocytes generating and conducting electrical signals in the …

Traditionally, cardiac electrophysiology has focused on myocytes—the heart muscle cells
that generate action potentials and are electrically excitable. Nonmyocytes within the heart …

The past 20 years have seen tremendous progress in the medical treatment of cardiac
diseases, a progress that actually translated into decreased cardiovascular morbidity and …

Cardiac excitation–contraction coupling (ECC) is the orchestrated process of initial myocyte
electrical excitation, which leads to calcium entry, intracellular trafficking, and subsequent …