In Plasmodium falciparum, perinuclear subtelomeric chromatin conveys monoallelic
expression of virulence genes. However, proteins that directly bind to chromosome ends are …

Background Epigenetic modifications of histones and regulation of chromatin structure have
been implicated in regulation of virulence gene families in P. falciparum. To better …

Plasmodium falciparum is the most deadly human malarial parasite, responsible for an
estimated 207 million cases of disease and 627,000 deaths in 2012. Recent studies reveal …

Proteins interacting with DNA are fundamental for mediating processes such as gene
expression, DNA replication and maintenance of genome integrity. Accumulating evidence …

Due to the unique selective pressures and extreme changes faced by the human malaria
parasite Plasmodium falciparum throughout its life cycle, the parasite has evolved distinct …

Chromosome ends have been implicated in the default silencing of clonally variant gene
families in the human malaria parasite Plasmodium falciparum. These chromosome regions …

In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-associated
processes and it is central to the control of gene expression. For Plasmodium falciparum, a …

Background Transcriptome-wide ribosome occupancy studies have suggested that during
the intra-erythrocytic lifecycle of Plasmodium falciparum, select mRNAs are post …

The human malaria parasite, Plasmodium falciparum, depends on a coordinated regulation
of gene expression for development and propagation within the human host. Recent …

Malaria, caused by Plasmodium parasites, is still one of the biggest global health
challenges. P. falciparum is the deadliest species to humans. In this review, we discuss how …