Downregulation of HDAC9 by the ketone metabolite β‐hydroxybutyrate suppresses vascular calcification
Z Lan, A Chen, L Li, Y Ye, Q Liang… - The Journal of …, 2022 - Wiley Online Library
Vascular calcification is an actively regulated process resembling bone formation and
contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD) …
contributes to the cardiovascular morbidity and mortality of chronic kidney disease (CKD) …
MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
DH Kwon, GH Eom, JH Ko, S Shin, H Joung… - Nature …, 2016 - nature.com
Vascular calcification (VC) is often associated with cardiovascular and metabolic diseases.
However, the molecular mechanisms linking VC to these diseases have yet to be elucidated …
However, the molecular mechanisms linking VC to these diseases have yet to be elucidated …
The short-chain fatty acid butyrate accelerates vascular calcification via regulation of histone deacetylases and NF-κB signaling
H Zhong, H Yu, J Chen, SWF Mok, X Tan, B Zhao… - Vascular …, 2022 - Elsevier
Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate,
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease …
propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease …
HDAC1‐mediated deacetylation of LSD1 regulates vascular calcification by promoting autophagy in chronic renal failure
J Zhou, H Zhou, C Liu, L Huang, D Lu… - Journal of Cellular and …, 2020 - Wiley Online Library
Chronic renal failure (CRF) is commonly associated with various adverse consequences
including pathological vascular calcification (VC), which represents a significant clinical …
including pathological vascular calcification (VC), which represents a significant clinical …
[HTML][HTML] New aspects of vascular calcification: histone deacetylases and beyond
Vascular calcification is a pathologic phenomenon in which calcium phosphate is ectopically
deposited in the arteries. Previously, calcification was considered to be a passive process in …
deposited in the arteries. Previously, calcification was considered to be a passive process in …
HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype
Aortic calcification is an important independent predictor of future cardiovascular events. We
performed a genome-wide association meta-analysis to determine SNPs associated with the …
performed a genome-wide association meta-analysis to determine SNPs associated with the …
ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease
L Ouyang, X Su, W Li, L Tang, M Zhang… - The Journal of …, 2021 - Am Soc Clin Investig
Vascular calcification (VC) predicts cardiovascular morbidity and mortality in chronic kidney
disease (CKD). To date, the underlying mechanisms remain unclear. We detected leukocyte …
disease (CKD). To date, the underlying mechanisms remain unclear. We detected leukocyte …
Hyaluronan negatively regulates vascular calcification involving BMP2 signaling
Y Kong, Q Liang, Y Chen, P Yang, X Liu, Y Li… - Laboratory …, 2018 - nature.com
Vascular calcification is a highly regulated biological process similar to bone formation
involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan …
involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan …
25-Hydroxycholesterol promotes vascular calcification via activation of endoplasmic reticulum stress
Q Dong, Y Chen, W Liu, X Liu, A Chen, X Yang… - European Journal of …, 2020 - Elsevier
Vascular calcification is a highly regulated process similar to osteogenesis involving
phenotypic change of vascular smooth muscle cells (VSMCs). 25-Hydroxycholesterol (25 …
phenotypic change of vascular smooth muscle cells (VSMCs). 25-Hydroxycholesterol (25 …
Celastrol attenuates arterial and valvular calcification via inhibiting BMP2/Smad1/5 signalling
Z Su, P Zong, J Chen, S Yang, Y Shen… - Journal of cellular …, 2020 - Wiley Online Library
Vascular calcification is an important risk factor for the mortality and morbidity in chronic
kidney disease (CKD). Unfortunately, until now there is no certain medication targeting …
kidney disease (CKD). Unfortunately, until now there is no certain medication targeting …
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