The prediction of disease risks is an essential part of personalized medicine, which includes
early disease detection, prevention, and intervention. The polygenic risk score (PRS) has …

Public health strategies aimed at disease prevention or early detection and intervention
have the potential to advance human health worldwide. However, their success depends on …

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

Genetic testing is used widely for diagnostic, carrier and predictive testing in monogenic
diseases. Until recently, there were no genetic testing options available for multifactorial …

Polygenic risk scores (PRS) estimate an individual's genetic likelihood of complex traits and
diseases by aggregating information across multiple genetic variants identified from genome …

Motivation It is hoped that advances in our knowledge in disease genomics will contribute to
personalized medicine such as individualized preventive strategies or early diagnoses of …

Polygenic risk scores (PRS) are an emerging precision medicine tool based on multiple
gene variants that, taken alone, have weak associations with disease risks, but collectively …

Increasing amounts of genetic data have led to the development of polygenic risk scores
(PRSs) for a variety of diseases. These scores, built from the summary statistics of genome …

Genes account for a significant proportion of the risk for most common diseases. The
genome-wide association scan (GWAS) era of genetic epidemiology has generated a …

Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …