Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-
metalloproteinases with thrombospondin motifs (ADAMTSs) have been implicated in the …

The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family
consists of 19 proteases. These enzymes are known to play important roles in development …

Irreversible degradation of articular cartilage is a major feature of the arthritides, and its
prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix …

Comparison of domain structures of ADAMTSs, ADAMs and SVMPs. The first three boxes of
each bar represent, respectively, the common prodomain and the metalloprotease and …

Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by the
destruction of joint tissues including cartilage and bone. Cartilage degradation is attributed …

Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)
family are known to influence development, angiogenesis, coagulation and progression of …

Matrix metalloproteinases (MMPs) and related enzymes (ADAMs, ADAMTS) and their
inhibitors control matrix turnover and function. Recent advances in our understanding of …