Design and synthesis of DNA hydrogel based on EXPAR and CRISPR/Cas14a for ultrasensitive detection of creatine kinase MB

M Chen, J Zhang, Y Peng, J Bai, S Li, D Han… - Biosensors and …, 2022 - Elsevier
Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems exhibit
significant potential in developing biosensing technology due to their collateral cleavage …

AND logic-gate-based CRISPR/Cas12a biosensing platform for the sensitive colorimetric detection of dual miRNAs

S Gong, X Wang, P Zhou, W Pan, N Li… - Analytical …, 2022 - ACS Publications
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-
associated) system has been widely explored for the detection of disease-related nucleic …

Designing a CRISPR/Cas12a-and Au-nanobeacon-based diagnostic biosensor enabling direct, rapid, and sensitive miRNA detection

T Luo, J Li, Y He, H Liu, Z Deng, X Long… - Analytical …, 2022 - ACS Publications
Direct, rapid, sensitive, and selective detection of nucleic acids in complex biological fluids is
crucial for medical early diagnosis. We herein combine the trans-cleavage ability of …

Spherical nucleic acid enzyme programmed network to accelerate CRISPR assays for electrochemiluminescence biosensing applications

Y Li, ML Liu, WB Liang, Y Zhuo, XJ He - Biosensors and Bioelectronics, 2023 - Elsevier
Given the targeted binding ability and cleavage activity of the emerging CRISPR/Cas12a
assay which transduces the target into its cleavage activity exhibited broadly prospective …

CRISPR/Cas13a catalyzed self-assembly of quantum dot-DNA hydrogel for microRNA assay

Y Yang, J Yang, Y Yang, X Ji, W Li, F Wang… - Sensors and Actuators B …, 2023 - Elsevier
Taking the advantages of outstanding precision in target recognition and trans-cleavage
ability, the RNA-guided CRISPR-Cas systems have shown great promise in cancer …

CRISPR/Cas12a-triggered chemiluminescence enhancement biosensor for sensitive detection of nucleic acids by introducing a tyramide signal amplification strategy

T Hu, X Ke, Y Ou, Y Lin - Analytical Chemistry, 2022 - ACS Publications
CRISPR-based biosensors have attracted increasing attention in accurate and sensitive
nucleic acid detection. In this work, we report a CRI SPR/Cas12a-triggered c …

Hollow covalent organic framework-sheltering CRISPR/Cas12a as an in-vivo nanosensor for ATP imaging

Y Pan, X Luan, F Zeng, Q Xu, Z Li, Y Gao, X Liu… - Biosensors and …, 2022 - Elsevier
In addition to applications in genome editing, clustered regularly interspaced short
palindromic repeats (CRISPR) have recently been engineered for medical diagnostics …

Enhanced chemiluminescence imaging sensor for ultrasensitive detection of nucleic acids based on HCR-CRISPR/Cas12a

X Ke, Y Ou, Y Lin, T Hu - Biosensors and Bioelectronics, 2022 - Elsevier
CRISPR/Cas systems have ignited increasing attention in accurate and sensitive nucleic
acids detection. In this work, we proposed the first CRISPR/Cas12a-based …

CRISPR/Cas12a system responsive DNA hydrogel for label-free detection of non-glucose targets with a portable personal glucose meter

W Ma, M Liu, S Xie, B Liu, L Jiang, X Zhang… - Analytica Chimica Acta, 2022 - Elsevier
In this work, personal glucose meter (PGM) as a portable electrochemical device was
utilized for sensitive detection of non-glucose targets: N-gene and PCB77, respectively. DNA …

Programming DNA walker and DNA tetrahedral nanostructures mediated CRISPR/Cas12a electrochemiluminescence biosystem and its biosensing application

Z Zhang, L Zhang, S Wang, R Liu, L Li, P Zhao… - Sensors and Actuators B …, 2023 - Elsevier
A CRISPR/Cas12a electrochemiluminescence (ECL) biosensor based on the multiple sites
DNA walker with controlled swing arm position, integrating Tribulus terrestris-like AuCu …