Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases

RK Burt, Y Loh, W Pearce, N Beohar, WG Barr, R Craig… - Jama, 2008 - jamanetwork.com
Context Stem cell therapy is rapidly developing and has generated excitement and promise
as well as confusion and at times contradictory results in the lay and scientific literature …

Stem cells in the treatment of disease

HM Blau, GQ Daley - New England Journal of Medicine, 2019 - Mass Medical Soc
Stem-Cell Research and Clinical Application Stem cells have been the focus of hope, hype,
and a great deal of research. But what exactly is a stem cell, and what are its uses? This …

A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial …

JM Hare, JH Traverse, TD Henry, N Dib… - Journal of the American …, 2009 - jacc.org
Objectives: Our aim was to investigate the safety and efficacy of intravenous allogeneic
human mesenchymal stem cells (hMSCs) in patients with myocardial infarction (MI) …

Mesenchymal stem cells and their potential as cardiac therapeutics

MF Pittenger, BJ Martin - Circulation research, 2004 - Am Heart Assoc
Mesenchymal stem cells (MSCs) represent a stem cell population present in adult tissues
that can be isolated, expanded in culture, and characterized in vitro and in vivo. MSCs …

Clarifying stem-cell therapy's benefits and risks

PW Marks, CM Witten, RM Califf - New England Journal of …, 2017 - Mass Medical Soc
Clarifying Stem-Cell Therapy’s Benefits and Risks | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Clinical trials for stem cell therapies

A Trounson, RG Thakar, G Lomax, D Gibbons - BMC medicine, 2011 - Springer
In recent years, clinical trials with stem cells have taken the emerging field in many new
directions. While numerous teams continue to refine and expand the role of bone marrow …

Clinical applications of stem cells for the heart

KC Wollert, H Drexler - Circulation research, 2005 - Am Heart Assoc
Repair of the heart is an old dream of physicians caring for patients with cardiac disease.
Experimental studies suggest that cardiac transfer of stem and progenitor cells can have a …

Safety and efficacy of intracoronary infusion of allogeneic human cardiac stem cells in patients with ST-segment elevation myocardial infarction and left ventricular …

F Fernández-Avilés, R Sanz-Ruiz, J Bogaert… - Circulation …, 2018 - Am Heart Assoc
Rationale: Allogeneic cardiac stem cells (AlloCSC-01) have shown protective,
immunoregulatory, and regenerative properties with a robust safety profile in large animal …

The clinical application of mesenchymal stem cells and cardiac stem cells as a therapy for cardiovascular disease

J Kim, L Shapiro, A Flynn - Pharmacology & Therapeutics, 2015 - Elsevier
Cardiovascular disease (CVD) can be separated into two broad etiological categories,
based on the presence or absence of ischemia as a causative factor. In both ischemic and …

Adult bone marrow stem cells regenerate myocardium in ischemic heart disease

D Orlic - Annals of the New York Academy of Sciences, 2003 - Wiley Online Library
Recent studies have demonstrated the existence of several populations of primitive cells in
mouse and human bone marrow that have the capacity, both in vitro and in vivo, to give rise …