Background Effective oral delivery of drugs remains a major challenge given their possible
undesirable physicochemical properties, physicochemical factors, and the physiological …

A large amount of absorptive intestinal membrane transporters play an important part in
absorption and distribution of several nutrients, drugs and prodrugs. The present paper …

Intestinal brush-border and basolateral membrane transport mechanisms for
monosaccharides, monocarboxylic acids, phosphate and several water-soluble vitamins are …

The oral route of drug administration remains the most popular and convenient route of
administration, despite its many shortcomings and challenges. Although the advantages …

While oral exposure continues to be the major focus, the chemical space of recent drug
discovery is apparently trending towards more hydrophilic libraries, due to toxicity and drug …

Although the oral route of drug administration is the most acceptable way of self-medication
with a high degree of patient compliance, the intestinal absorption of many drugs is severely …

Poor oral bioavailability for many drugs is generally attributed to poor solubility in the
gastrointestinal fluids, poor gut membrane permeability and/or extensive hepatic first-pass …

The oral route is the most common and practical means of drug administration, particularly
from a patient's perspective. However, the pharmacokinetic profile of oral drugs depends on …

A wide variety of transporters are found in the intestine, and are involved in the membrane
transport of daily nutrients as well as drugs. These intestinal transporters are located in the …

Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …