CDK5 est une protéine kinase atypique appartenant à la famille des CDKs découverte dans
le système nerveux central où elle y est majoritairement exprimée et a longtemps été …

CDK5 est une protéine kinase atypique appartenant à la famille des CDKs découverte dans
le système nerveux central où elle y est majoritairement exprimée et a longtemps été …

Recent studies have uncovered various physiological functions of CDK5 in many
nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes …

Simple Summary CDK5 is a serine/threonine type kinase that is mainly found in nerves. It is
a target that has been studied primarily in neurological disorders, but recently it has been …

Abstract Cyclin-dependent kinase 3 (CDK3) is a major player driving retinoblastoma (Rb)
phosphorylation during the G 0/G 1 transition and in the early G 1 phase of the cell cycle …

Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the
central nervous system rather than in the cell cycle. However, Cdk5 has been recently …

Highlights•The wide functionality of CDK12 in a cell-specific manner.•Rationale for using
CDK12 as a biomarker and therapeutic target.•Structural dissection of CDK12 associated …

Abstract Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase belonging to the
CDK family, firstly discovered as a major player of neuronal development, bet several …

The transcription cycle of RNA polymerase II (Pol II) is regulated by a set of cyclin-dependent
kinases (CDKs). Cdk7, associated with the transcription initiation factor TFIIH, is both an …

Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are
traditionally activated upon association with a regulatory subunit. For most CDKs, activation …