Nuclear mechanotransduction has been implicated in the control of chromatin organization;
however, its impact on functional contractile myofibers is unclear. We found that deleting …

Mechanical stress controls a broad range of cellular functions. The cytoskeleton is physically
connected to the extracellular matrix via integrin receptors, and to the nuclear lamina by the …

The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex transduces nuclear
mechanical inputs suggested to control chromatin organization and gene expression; …

Regulation of the genome is viewed through the prism of gene expression, DNA replication
and DNA repair as controlled through transcription, chromatin compartmentalisation and …

Skeletal muscle demonstrates a high degree of adaptability in response to changes in
mechanical input. The phenotypic transformation in response to mechanical cues includes …

Many signaling pathways converge on the nucleus to regulate crucial nuclear events such
as transcription, DNA replication and cell cycle progression. Although the vast majority of …

In the eukaryotic cell nucleus, actin and myosin are emerging as essential regulators of
nuclear function. At gene level, they regulate chromatin and modulate RNA polymerase …

Mechanical integration of the nucleus with the extracellular matrix (ECM) is established by
linkage between the cytoskeleton and the nucleus. This integration is hypothesized to …

Structural links from the nucleus to the cytoskeleton and to the extracellular environment
play a role in direct mechanosensing by nuclear factors. Here, we highlight recent studies …

Mechanical forces are known to influence cellular processes with consequences at the
cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is …