Tumor cells overcome anti‐tumor responses in part through immunosuppressive
mechanisms. There are several immune modulatory mechanisms. Among them, adenosine …

The adenosinergic pathway plays an important role in cancer progression. Aside from
regulating functions of tumor cells and tissue cells present in the tumor microenvironment …

Adenosine, an immunosuppressive metabolite, is produced by adenosine triphosphate
(ATP) released from dying or stressed cells and is found at high levels in the tumor …

The immune system plays a major role in the surveillance and control of malignant cells,
with the presence of tumor infiltrating lymphocytes (TILs) correlating with better patient …

Cancer is a chronic disease and its pathogenesis is well correlated with infection and
inflammation. Adenosine is a purine nucleoside, which is produced under metabolic stress …

A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in
many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc …

Tumor cells use various ways to evade anti‐tumor immune responses. Adenosine, a potent
immunosuppressive metabolite, is often found elevated in the extracellular tumor …

The adenosine pathway plays a key role in modulating immune responses in physiological
and pathological conditions. Physiologically, anti-inflammatory effects of adenosine balance …

Increasing evidence supports targeting the adenosine pathway in immuno-oncology with
several clinical programs directed at adenosine A2 receptor (A2AR, A2BR), CD73 and …

Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled
receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3 …