Chitosan is among the few polymers with high biocompatibility and low toxicity. In the area of
siRNA delivery, chitosan has been noted for its high buffer capacity in endosomal pH range …

Chitosan (CS) nanoparticles have been extensively studied for siRNA delivery; however,
their stability and efficacy are highly dependent on the types of cross-linker used. To address …

The ability to specifically silence genes using siRNA has enormous potential for treating
genetic diseases. However, siRNA instability and biodistribution issues still need to be …

Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

This study aims at developing chitosan-based nanoparticles suitable for an intravenous
administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing …

Gene silencing mediated by double-stranded small interfering RNA (siRNA) has been
widely investigated as a potential therapeutic approach for diseases with genetic defects …

The low transfection efficiency of chitosan is one of its drawbacks as a gene delivery carrier.
Low molecular weight chitosan may help to form small-sized polymer-DNA or small …

The aim of this study was to investigate chitosan/siRNA complexes formulated with various
chitosan salts (CS) including chitosan aspartate (CS-Asp), chitosan glutamate (CS-Glu) …

Small interfering RNA (siRNA) has been widely investigated as a potential therapeutic for
treatment of various diseases. However, the use of siRNA is limited due to its rapid …

Chitosan (CS) shows in vitro and in vivo efficacy for siRNA delivery but with contradictory
findings for incompletely characterized systems. For understanding which parameters …