Expression of the immediate-early response gene IER2 has been associated with the
progression of several types of cancer, but its functional role is poorly understood. We found …

Here, we report unbiased screens for genes expressed in metastatic tumor cells that are
associated with cell motility. These screens identified Ier2, an immediate early gene of …

The expression of immediate early response 3 (IER3), a protein with a short half-life, is
rapidly induced by various cellular stimuli. We recently reported that IER3 induces the …

Background Immediate early response gene 3 (IER3) is a stress-inducible gene, which
exerts diverse effects in regulating cell apoptosis and cell cycle. Growing evidence shows …

Cell senescence contributes to organismal aging and is induced by telomere erosion and an
ensuing DNA damage signal as cells reach the end of their replicative lifespan in vitro or in …

Cellular senescence, the limited ability of cultured normal cells to divide, can result from
cellular damage triggered through oncogene activation (premature senescence) or the loss …

Recent evidence demonstrates that senescence acts as a barrier to tumorigenesis in
response to oncogene activation. Using a mouse model of breast cancer, we tested the …

Human immediate early response 2 (IER2) has been reported to function as a potential
transcriptional factor or transcriptional co‑activator and seems to play a pivotal role in tumor …

Background Previous work has demonstrated YPEL3 to be a growth-suppressive protein
that acts through a pathway of cellular senescence. We set out to determine whether human …

Abstract Background The IRE1α-XBP1 pathway is the most conserved branch of the
unfolded protein response pathways, which are activated during endoplasmic reticulum …