[HTML][HTML] SERCA overexpression improves mitochondrial quality control and attenuates cardiac microvascular ischemia-reperfusion injury
Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury,
coronary circulation is a so far neglected target of cardioprotection. In this study, we …
coronary circulation is a so far neglected target of cardioprotection. In this study, we …
[HTML][HTML] SERCA overexpression reduces reperfusion-mediated cardiac microvascular damage through inhibition of the calcium/MCU/mPTP/necroptosis signaling …
Endothelial cells lining the microvasculature are particularly vulnerable to the deleterious
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …
effects of cardiac ischemia/reperfusion (I/R) injury, a susceptibility that is partially mediated …
Cardioprotection of post-ischemic moderate ROS against ischemia/reperfusion via STAT3-induced the inhibition of MCU opening
L Wu, JL Tan, ZY Chen, G Huang - Basic research in cardiology, 2019 - Springer
Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …
[HTML][HTML] An overview of the molecular mechanisms associated with myocardial ischemic injury: state of the art and translational perspectives
L Schirone, M Forte, L D'Ambrosio, V Valenti… - Cells, 2022 - mdpi.com
Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
cardiovascular diseases, myocardial infarction represents a life-threatening condition …
HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury
J Yang, J He, M Ismail, S Tweeten, F Zeng… - Journal of molecular and …, 2019 - Elsevier
Aims The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic
acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt …
acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt …
[HTML][HTML] Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury
Cardiovascular disease is the most common cause of death worldwide and in particular,
ischemic heart disease holds the most considerable position. Even if it has been deeply …
ischemic heart disease holds the most considerable position. Even if it has been deeply …
[HTML][HTML] Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury
J Wang, H Zhou - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …
[HTML][HTML] Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 …
TL Lee, TC Lai, SR Lin, SW Lin, YC Chen, CM Pu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Cardiovascular diseases, such as myocardial infarction (MI), are the leading
causes of death worldwide. Reperfusion therapy is the common standard treatment for MI …
causes of death worldwide. Reperfusion therapy is the common standard treatment for MI …
NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux
YJ Zhang, M Zhang, X Zhao, K Shi, M Ye, J Tian… - Basic Research in …, 2020 - Springer
Microvascular damage is a key pathological change in myocardial ischemia/reperfusion
(I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first …
(I/R) injury. Using a rat model of myocardial I/R, our current study has provided the first …
[HTML][HTML] Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model
X Yao, D Carlson, Y Sun, L Ma, SE Wolf, JP Minei… - PloS one, 2015 - journals.plos.org
We have previously shown that mitochondria-targeted vitamin E (Mito-Vit-E), a mtROS
specific antioxidant, improves cardiac performance and attenuates inflammation in a …
specific antioxidant, improves cardiac performance and attenuates inflammation in a …
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- cardiac ischemia reperfusion injury
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- cardiac ischemia molecular targets
- molecular targets reperfusion injury
- cardiac injury stem cells
- mitochondrial ros mtdna damage
- cardiac ischemia autophagic flux
- cardiac injury conditioned medium