The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

ABSTRACT A hallmark of the mammalian immune system is its ability to respond efficiently
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …

Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …

Adaptive immunity is initiated in secondary lymphoid tissues when naive T cells recognize
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …

The lymph node is a highly organized and dynamic structure that is critical for facilitating the
intercellular interactions that constitute adaptive immunity. Most ex vivo studies of the lymph …

A central feature of the immune system is the migratory behavior of its cellular components.
Thus, fully understanding the generation and maintenance of immune responses must …

Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …

Lymphoid stromal cells are best known as the architectural cells of lymphoid organs. For
decades, they have been considered as inert elements of the immune system but this view …

Dendritic cells (DCs) capture pathogens and foreign antigen (Ag) in peripheral tissues and
migrate to secondary lymphoid tissues, such as lymph nodes (LNs), where they present …

Two‐photon microscopy is providing literal insight into the cellular dynamics of lymphoid
organs and, guided by analysis of three‐dimensional images, into mechanisms that underlie …