Objective Recent studies suggest that white matter hyperintensities (WMH) on MRI, which
primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of …

Introduction It is unclear whether white matter hyperintensities (WMHs), magnetic resonance
imaging markers of small-vessel cerebrovascular disease, promote neurodegeneration and …

This study investigated the relationship between white matter hyperintensities (WMH) and
cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Subjects included 180 …

The association between cerebrovascular disease pathology (measured by white matter
hyperintensities, WMH) and brain atrophy in early Alzheimer's disease (AD) remain to be …

Objective To determine the relationship between white matter hyperintensities (WMH)
presumed to indicate disease of the cerebral small vessels, temporal lobe atrophy, and …

There is growing evidence that vascular health plays a significant role in the etiology of
clinical Alzheimer's disease (AD). Understanding the timing of vascular changes in relation …

Background To promote the development of effective therapies, there is an important need
to characterize the full spectrum of neuropathological changes associated with Alzheimer's …

White matter hyperintensities (WMHs), a marker of small-vessel cerebrovascular disease,
increase risk for mild cognitive impairment (MCI). Less is known about whether regional …

Accumulating evidence implicates small vessel cerebrovascular disease, visualized as
white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the …

Background Longitudinal investigations are needed to improve understanding of the
contributions of cerebral small vessel disease to the clinical manifestation of Alzheimer's …