[HTML][HTML] Mechanisms of anthracycline-induced cardiotoxicity: is mitochondrial dysfunction the answer?
A Murabito, E Hirsch, A Ghigo - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Cardiac side effects are a major drawback of anticancer therapies, often requiring the use of
low and less effective doses or even discontinuation of the drug. Among all the drugs known …
low and less effective doses or even discontinuation of the drug. Among all the drugs known …
[HTML][HTML] Understanding anthracycline cardiotoxicity from mitochondrial aspect
J Huang, R Wu, L Chen, Z Yang, D Yan… - Frontiers in …, 2022 - frontiersin.org
Anthracyclines, such as doxorubicin, represent one group of chemotherapy drugs with the
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …
most cardiotoxicity. Despite that anthracyclines are capable of treating assorted solid tumors …
Anthracyclines and mitochondria
A Mordente, E Meucci, A Silvestrini… - Advances in …, 2012 - Springer
Anthracyclines remain the cornerstone in the treatment of many malignancies including
lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent …
lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent …
Effects of doxorubicin‐induced cardiotoxicity on cardiac mitochondrial dynamics and mitochondrial function: Insights for future interventions
N Osataphan, A Phrommintikul… - Journal of Cellular …, 2020 - Wiley Online Library
Anthracyclines is an effective chemotherapeutic treatment used for many types of cancer.
However, high cumulative dosage of anthracyclines leads to cardiac toxicity and heart …
However, high cumulative dosage of anthracyclines leads to cardiac toxicity and heart …
Signaling pathways underlying anthracycline cardiotoxicity
Significance: The cardiac side effects of hematological treatments are a major issue of the
growing population of cancer survivors, often affecting patient survival even more than the …
growing population of cancer survivors, often affecting patient survival even more than the …
[HTML][HTML] Novel mechanisms of anthracycline-induced cardiovascular toxicity: a focus on thrombosis, cardiac atrophy, and programmed cell death
S Antoniak, S Phungphong, Z Cheng… - Frontiers in …, 2022 - frontiersin.org
Anthracycline antineoplastic agents such as doxorubicin are widely used and highly
effective component of adjuvant chemotherapy for breast cancer and curative regimens for …
effective component of adjuvant chemotherapy for breast cancer and curative regimens for …
Role of Oxidative Stress in the Mechanisms of Anthracycline‐Induced Cardiotoxicity: Effects of Preventive Strategies
R Carrasco, RL Castillo, JG Gormaz… - Oxidative medicine …, 2021 - Wiley Online Library
Anthracycline‐induced cardiotoxicity (AIC) persists as a significant cause of morbidity and
mortality in cancer survivors. Although many protective strategies have been evaluated …
mortality in cancer survivors. Although many protective strategies have been evaluated …
Mitochondrial determinants of doxorubicin-induced cardiomyopathy
KB Wallace, VA Sardão, PJ Oliveira - Circulation research, 2020 - Am Heart Assoc
Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
progressively developing cardiomyopathy. Doxorubicin is one of the most highly prescribed …
Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage
CA Geisberg, DB Sawyer - Current hypertension reports, 2010 - Springer
Anthracyclines are common chemotherapeutic agents used to treat many different types of
cancer. Unfortunately, the use of anthracyclines is limited by their cardiotoxic effects, which …
cancer. Unfortunately, the use of anthracyclines is limited by their cardiotoxic effects, which …
[HTML][HTML] Anthracycline-induced cardiotoxicity—are we about to clear this hurdle?
WCM Dempke, R Zielinski, C Winkler… - European Journal of …, 2023 - Elsevier
Anthracyclines have contributed significantly to remarkable improvements in overall survival
and are regarded as the most effective cytostatic drug for cancer treatment in various …
and are regarded as the most effective cytostatic drug for cancer treatment in various …