The academic literature on and industrial practice of control of solution crystallization
processes have seen major advances in the past 15 years that have been enabled by …

A key bottleneck in the production of pharmaceuticals and many other products is the
formation of crystals from solution. The control of the crystal size distribution can be critically …

Crystallization is the main separation and purification process for the manufacturing of drug
substances. Not only does crystallization affect the efficiency of downstream operations such …

Crystallization is the most important unit operation for the separation and purification of
chemicals in the pharmaceutical and fine chemical industries. Crystallization processes in …

Crystallization is one of the most important unit operations used for the separation and
purification of crystalline solid products. Appropriate design and control of the crystallization …

Recent advances in in situ measurement technology and automation of batch crystallizers
have enabled the development of batch crystallization recipes in which the desired …

Purity is a critical quality attribute for both pharmaceutical and biopharmaceutical products.
The presence of impurities (solvents, salts, or byproducts of the synthetic path) in drugs can …

Crystallization, as a solid–liquid separation process, is employed to purify and isolate a
great diversity of crystalline pharmaceutical products. In recent years, continuous …

The objective of every industrial crystallization process is to create crystals that meet
specifications on size, shape, composition, and internal structure. This objective is achieved …

Crystallization is one of the oldest separation and purification unit operations, and has
recently contributed to significant improvements in producing higher-value products with …